Full Professor Lecturing: Elements in Control and Robotics (undergraduate) and Elements in Control Technology (undergraduate), Modelling, Identification and Simulation of Biological Systems (graduate), Feedback Loop in Biological Systems (graduate) E-mail: ales[dot]belic[at]fe[dot]uni-lj[dot]si Tel: +386 (0)1 4768-762 Room no.: A205

I received B.Sc and Ph.D. in electrical engineering from the University of Ljubljana, Slovenia in  
1994, and 2000 respectively. Main areas of my professional interest are artificial intelligence modelling techniques in pharmacokinetics and pharmacodynamics and modelling in bio-medical area. Curently I am involved in modelling of Cholesterol pathways in human in the frame of 6th European Framework project STEROLTALK, and in functional analysis of EEG signals (picture taken after 40h sleep-deprivation experiment at the Institute for Clinical Neurophysyology).

Selected references:

• A. BELIČ, K. TÓTH, R. VRZAL, M. TEMESVÁRY, P. PORROGI, E ORBÁN, D. ROZMAN, Z. DVORAK, K. MONOSTORY. Dehydroepiandrosterone post-transcriptionally modifies CYP1A2 induction involving androgen receptor. Chemico-biological interactions, vol. 203, issue 3, pp. 597-603, doi: 10.1016/j.cbi.2013.04.002., 2013.
• A. Belič, D. Pompon, K. Monostory, D. Kelly, S. L. Kelly, D. Rozman. An algorithm for rapid computational construction of metabolic networks : a cholesterol biosynthesis example. Computers in Biology and Medicine, vol. 43, no. 5, pp. 471-480, doi:10.1016/j.compbiomed.2013.02.017, 2013.
• A. Belič, J. Ačimovič, A. Naik, M. Goličnik. Analysis of the steady-state relations and control-algorithm characterisation in a mathematical model of cholesterol biosynthesis. Simulation modelling practice and theory (special issue), vol. 33, pp. 18-27, doi: 10.1016/j.simpat.2011.12.010., 2013.
• J. Jeran, B Koritnik, I. Zidar, A. Belič, J. Zidar. Sniffing-related motor cortical potential: topography and possible generators. Respiratory physiology & neurobiology, vol. 185, no. 2, pp. 249-256, doi: 10.1016/j.resp.2012.10.006., 2012.
• M. TEMESVÁRI, L. KÓBORI, J. PAULIK, E. SÁRVÁRY, A. BELIČ, K. MONOSTORY. Estimation of drug-metabolizing capacity by cytochrome P450 genotyping and expression. The Journal of pharmacology and experimental therapeutics, vol. 341, no. 1, pp. 294-305, doi: 10.1124/jpet.111.189597, 2012.
• V. Logar, A. Belič. A possible use of EEG signals in a brain-computer interface. Zdravniški vestnik, Vol. 80, No. 2, pp. 92-97, 2011.
• V. Logar, A. Belič. Brain-computer interface analysis od a dynamic visuo-motor task. Artificial intelligence in medicine, Vol. 51, No. 1, 2011.
• J. Ačimovič, T. Korošec, M. Seliškar, I. Bjorkhem, K. Monostory, P. Szabo, J.-M. Pascussi, A. Belič, U. Urleb, D. Kocjan, D. Rozman. Inhibition of human sterol delta 7-reductase and other post-lanosterol enzymes by 2-(4-phenethylpiperazin-1-yl)-1-(pyridine-3-yl)ethanol (LK-980), a novel inhibitor of cholesterol synthesis. Drug Metabolisim and Disposition doi:10.1124/dmd.110.035840, 2010.
• A. Belič, M. Temesvari, K. Kohalmy, R. Vrzal, Z. Dvorak, D. Rozman, K. Monostory. Investigation of the CYP2C9 induction profile in human hepatocytes by combining experimental and modelling approaches. Current Drug Metabolism, vol. 10, no. 10, pp. 1066-1074, 2009.
• A. Belič, I. Škrjanc, D. Zupančič-Božič, F. Vrečer. Tableting process optimisation with the application of fuzzy models. International Journal of Pharmaceutics vol. 389 no. 1/2, pp., 2009.
• A. Belič. Modelling in systems biology, neurology and pharmacy. Math. comput. model. dyn. syst. vol. 15, no. 6, pp. 479-491, 2009.
• A. Belič, I. Škrjanc, D. Zupančič-Božič, R. Karba, F. Vrečer. Minimisation of the capping tendency by tableting process optimisation with the application of artificial neural networks and fuzzy models. European Journal of Pharmaceutics and Biopharmaceutics, vol 73, no. 1, pp. 172-178, 2009.
• P. Juvan, T. Režen, D. Rozman, K. Monostory, J.-M. Pascussi, A. Belič. Towards identification of gene interaction networks of human cholesterol biosynthesis. Acta Chim. Slov, vol 55. No. 2, pp. 396-407, 2008.
• V. Logar, A. Belič, B. Koritnik, S. Brežan, J. Zidar, R. Karba, D. Matko. Using ANNs to predict a subject's response based on EEG traces. Neural Networks, Volume 21, Issue 7 pp. 881-887, 2008.
• Grabnar I., M. Bogataj, A. Belič, V. Logar, R. Karba, A. Mrhar. Kinetic model of drug distribution in the urinary bladder wall following intravesical instillation. Int. J. of Pharmaceutics, vol. 322, no. 1-2, pp. 52-59, 2006.
• Belič A., I. Grabnar, I. Belič, R. Karba and A. Mrhar. Predicting the anti-hypertensive effect of nitrendipine from plasma concentration profiles using artificial neural networks. Computers in Biology and Medicine, Vol. 35, pp. 892-904, 2005.
• Belič A., I. Grabnar, R. Karba and A. Mrhar. Pathways of paracetamol absorption from layered excipient suppositories: artificial intelligence approch. Eur. j. drug metab. pharmakokinet., vol. 28, no. 1, pp. 31-40, 2003.
• Belič, A., I. Grabnar, R. Karba, A. Mrhar, T. Irman-Florjanc, S. Primožič. Interdependence of histamine and methylhistamine kinetics: modelling and simulation approach. Computers in Biology and Medicine, Vol. 29, pp. 361-375, 1999.
• Chicco, D., I. Grabnar, A. Škerjanec, D. Vojnovic, V. Maurich, N. Realdon, E. Ragazzi, A. Belič, R. Karba, A. Mrhar. Correlation of in vitro and in vivo paracetamol availability from layered excipient suppositories. Int. J. of Pharmaceutics, Vol. 189, pp. 147-160, 1999.
• Beovič, B., A. Mrhar, R. Karba, T. Župančič, I. Grabnar, A. Belič, M. Marolt Gomišček. Influence of fever on the pharmacokinetics of ciprofloxacin. Int. J. of Antimicrobial Agents, Vol. 11, pp. 81-85, 1999.
• I. Grabnar, A. Belic, A. Mrhar, R. Karba. The role of pharmacokinetic modelling and computer simulation in drug formulation design. Ledley, R.S. and Gersak, B. (eds.). Computers in Biology and Medicine: 9th International Conference on Mechanics in Medicine and Biology, (Computers in biology and medicine), Vol. 28, no. 4, New York: Pergamon, pp. 365-376, 1998.
• Karba, R., A. Belič, M. Klopčič, I. Škrjanc, I. Belič, A. Mrhar, I. Grabnar, S. Milanič, M. Atanasijević-Kunc. Some Artificial Intelligence and Control Approaches to Pharmacokinetic - Pharmacodynamic Modelling. SAMS, Vol. 35, pp. 75-85, 1999.

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